Efficacy and safety of ceritinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer: A systematic review and meta-analysis

Efficacy and safety of ceritinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer: A systematic review and meta-analysis

Ceritinib is a brand new, oral, potent and selective second-generation anaplastic lymphoma kinase (ALK) inhibitor permitted by the Food and Drug Administration of the United States in April 2014. It is lively in crizotinib-resistant sufferers, particularly in sufferers with non-small cell lung most cancers (NSCLC) and mind metastasis. The intention of this research was to …

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A systematic review and meta-analysis of biofeedback therapy for dyssynergic defaecation in adults

A systematic review and meta-analysis of biofeedback therapy for dyssynergic defaecation in adults

Dyssynergic defaecation is a typical type of purposeful constipation that responds poorly to conservative interventions. This systematic review and meta-analysis assesses the effectiveness of biofeedback therapy for dyssynergic defaecation utilizing world scientific enchancment as the first final result, and decision of the dyssynergic sample on anorectal physiology and high quality of life as secondary outcomes. …

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Clinicopathological characteristics of 8697 patients with COVID-19 in China: a meta-analysis

Clinicopathological characteristics of 8697 patients with COVID-19 in China: a meta-analysis

Our examine goals to current a abstract of the clinicopathological characteristics of patients affected by the coronavirus illness 2019 (COVID-19) that can be utilized as a reference for additional analysis and medical choices. Studies had been included in the meta-analysis if that they had cohort, case-control or case sequence designs and offered adequate particulars on …

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Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19

Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19

The novel extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2), additionally known as COVID-19, has brought on a pandemic which has swiftly concerned the complete world and raised nice public well being considerations. The scientific group is actively exploring remedies that might doubtlessly be efficient in combating COVID-19. Hydroxychloroquine has been demonstrated to restrict the replication …

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A general view of CD33+ leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy

Acute myeloblastic leukemia (AML) is the most frequent acute leukemia in adulthood with very poor overall survival rates. In the past few decades, significant progresses had led to the findings of new therapeutic approaches and the better understanding of the molecular complexity of this hematologic malignancy. Leukemic stem cells (LSCs) play a key role in …

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Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders

Neurodevelopmental disorders are characterized by deficits in communication, cognition, attention, social behavior and/or motor control. Previous studies have pointed to the involvement of genes that regulate synaptic structure and function in the pathogenesis of these disorders. One such gene, GRM7, encodes the metabotropic glutamate receptor 7 (mGlu7¬†), a G protein-coupled receptor that regulates pre-synaptic neurotransmitter …

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Rhizosphere allocation by canopy-forming species dominates soil CO2 efflux in a subarctic landscape

In arctic ecosystems, climate change has increased plant productivity. As arctic carbon (C) stocks are predominantly located below ground, the effects of greater plant productivity on soil C storage will significantly determine the net sink/source potential of these ecosystems, but vegetation controls on soil CO2¬†efflux remain poorly resolved. To identify the role of canopy-forming species …

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