Acute myeloblastic leukemia (AML) is the most frequent acute leukemia in adulthood with very poor overall survival rates. In the past few decades, significant progresses had led to the findings of new therapeutic approaches and the better understanding of the molecular complexity of this hematologic malignancy. Leukemic stem cells (LSCs) play a key role in …

A general view of CD33+ leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy Read More »

Neurodevelopmental disorders are characterized by deficits in communication, cognition, attention, social behavior and/or motor control. Previous studies have pointed to the involvement of genes that regulate synaptic structure and function in the pathogenesis of these disorders. One such gene, GRM7, encodes the metabotropic glutamate receptor 7 (mGlu7 ), a G protein-coupled receptor that regulates pre-synaptic neurotransmitter …

Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders Read More »

In arctic ecosystems, climate change has increased plant productivity. As arctic carbon (C) stocks are predominantly located below ground, the effects of greater plant productivity on soil C storage will significantly determine the net sink/source potential of these ecosystems, but vegetation controls on soil CO2 efflux remain poorly resolved. To identify the role of canopy-forming species …

Rhizosphere allocation by canopy-forming species dominates soil CO2 efflux in a subarctic landscape Read More »